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KMID : 1001020210190040244
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Journal of Urologic Oncology
2021 Volume.19 No. 4 p.244 ~ p.251
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Utility of Urinalysis as a Follow-up Surveillance Tool in Nonmuscle Invasive Bladder Cancer
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Park Min-Uk
Lim Bum-Jin
You Dal-San
Jeong In-Gab
Song Che-Ryn
Hong Bum-Sik
Kim Choung-Soo
Ahn Han-Jong
Hong Jun-Hyuk
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Abstract
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Purpose: To evaluate the association between microscopic hematuria (MH) detected by sur-veillance urinalysis and cancer recurrence in nonmuscle invasive bladder cancer (NMIBC) patients.
Materials and Methods: A total of 1,082 NMIBC patients who underwent transurethral resection of bladder tumor (TURB) procedures at Asan Medical Center between January 2017 and December 2019 were included. We retrospectively reviewed the follow-up data for these cases including cystoscopy, urinalysis, and urine cytology. The association between urine testing and cancer recurrence was assessed by both univariable and multivariable logistic regression analy-sis.
Results: The study patients had a median age of 68 years (interquartile range, 60?75 years) and comprised 898 men and 184 women. Among the 1,428 TURB procedures conducted in this series, 548 of the lesions (38.4%) were diagnosed as low-grade and 880 (61.6%) as high-grade cancers. A total of 3,309 follow-up cystoscopies were conducted during the study period and were divided into high-grade (HG) (2,011 cases) and low-grade (LG) (1,298 cases) groups according to the latest TURB pathology. MH was found to have a statistically significant association with NMIBC recurrence in both the LG (odds ratio [OR], 1.57; 95% confidence interval [CI], 1.107?2.223; p=0.011) and HG (OR, 1.90; 95% CI, 1.434?2.517; p<0.001) groups.
Conclusions: Urinalysis during follow-up may provide important information on cancer recur-rence in NMIBC patients.
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KEYWORD
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Nonmuscle invasive bladder cancer, Follow-up, Urinalysis, Microscopic hematuria
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